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The conversation about peptides is happening without the evidence.
Substrate is where the two meet.
The conversation about peptides is happening without the evidence.
Substrate is where the two meet.
People are using GLP-1s, BPC-157, Melanotan II, and dozens of peptide blends — sourced from group chats, TikTok, and grey-market vials, dosed on advice from strangers. The information they trust and the information that's actually been tested have come apart. That's a trust problem, not just a pharmacology problem — and it's the problem this site exists to close.
We don't tell you what to take. We tell you what's known, what isn't, and how to tell the difference — so whatever you decide, you decide with the real picture.
People are using GLP-1s, BPC-157, Melanotan II, and dozens of peptide blends — sourced from group chats, TikTok, and grey-market vials, dosed on advice from strangers. The information they trust and the information that’s actually been tested have come apart. That’s a trust problem, not just a pharmacology problem — and it’s the problem this site exists to close.
We don’t tell you what to take. We tell you what’s known, what isn’t, and how to tell the difference — so whatever you decide, you decide with the real picture.
What this is
What this is
Substrate is an independent, evidence-first reference on the peptides and GLP-1 drugs people are using off-label and buying on the grey market. For each one, it lays the community conversation next to what the clinical evidence actually shows — labelled by how strong that evidence is, and Canada-first on regulatory status (Health Canada).
It's built by a medical-sciences student, not a seller and not a clinic — every clinical claim is cited to a source you can check.
Substrate is an independent, evidence-first reference on the peptides and GLP-1 drugs people are using off-label and buying on the grey market. For each one, it lays the community conversation next to what the clinical evidence actually shows — labelled by how strong that evidence is, and Canada-first on regulatory status (Health Canada).
It’s built by a medical-sciences student, not a seller and not a clinic — every clinical claim is cited to a source you can check.
What it isn’t
What it isn’t
It doesn't tell you what to take, how much, or where to get it. It won't give you a dose. It doesn't sell anything, run ads, or collect your information.
And it's honest about what the marketing hides: the compounds with the strongest evidence are the ones a company paid to study. The ones with no evidence often have none because no one funded the trial — not because they're proven safe.
It's a library, not a service — not a substitute for a clinician who can see your full history.
It doesn’t tell you what to take, how much, or where to get it. It won’t give you a dose. It doesn’t sell anything, run ads, or collect your information.
And it’s honest about what the marketing hides: the compounds with the strongest evidence are the ones a company paid to study. The ones with no evidence often have none because no one funded the trial — not because they’re proven safe.
It’s a library, not a service — not a substitute for a clinician who can see your full history.
Start where you are
Start where you are
"I'm looking into a specific compound."
“I’m looking into a specific compound.”
The compound pages: Semaglutide · Tirzepatide · Retatrutide · Melanotan II · BPC-157
"Someone told me about a stack or a blend."
“Someone told me about a stack or a blend.”
Stacks & blends: Wolverine, GLOW, KLOW, CJC-1295 + Ipamorelin — and why premixed blends carry a risk the single compounds don't.
Stacks & blends: Wolverine, GLOW, KLOW, CJC-1295 + Ipamorelin — and why premixed blends carry a risk the single compounds don’t.
"I've decided to use something. How do I lower my risk?"
“I’ve decided to use something. How do I lower my risk?”
The harm-reduction core: why we won't give you a number · the reconstitution math · the rescue gap · how to talk to your clinician.
The harm-reduction core: why we won’t give you a number · the reconstitution math · the rescue gap · how to talk to your clinician.
"I keep seeing terms I don't recognize."
“I keep seeing terms I don’t recognize.”
How to read the discourse: the slang, the marketing language, and why "99% pure" doesn't mean what you think.
How to read the discourse: the slang, the marketing language, and why “99% pure” doesn’t mean what you think.
Compounds
Compounds
Semaglutide
Semaglutide
A
Tirzepatide
Tirzepatide
A
The dual-agonist that beat semaglutide head-to-head and is FDA-approved.
The dual-agonist that beat semaglutide head-to-head and is FDA-approved.
Retatrutide
Retatrutide
B
The frontier triple-agonist pending FDA approval—no approved product yet, aliases 'reta.'
The frontier triple-agonist pending FDA approval—no approved product yet, aliases ‘reta.’
Orforglipron
Orforglipron
B
The oral, non-peptide GLP-1 pill: early-phase data, not yet approved.
The oral, non-peptide GLP-1 pill: early-phase data, not yet approved.
MK-677 (Ibutamoren)
MK-677 (Ibutamoren)
B
An oral growth-hormone secretagogue with one solid trial and open questions.
An oral growth-hormone secretagogue with one solid trial and open questions.
BPC-157
BPC-157
C
The backbone of healing stacks, but Phase 1 data is thin and mostly in animals.
The backbone of healing stacks, but Phase 1 data is thin and mostly in animals.
TB-500 (Thymosin β4)
TB-500 (Thymosin β4)
C
The healing half of Wolverine and GLOW, but human data is sparse and confounded.
The healing half of Wolverine and GLOW, but human data is sparse and confounded.
KPV
KPV
C
An anti-inflammatory tripeptide with virtually no human trial data.
An anti-inflammatory tripeptide with virtually no human trial data.
Melanotan II
Melanotan II
C-harm
The tanning peptide with melanoma and renal-infarction concerns that swamp the data.
The tanning peptide with melanoma and renal-infarction concerns that swamp the data.
The most-studied GLP-1 drug for weight loss and diabetes, anchored on Phase 3 trials.
The most-studied GLP-1 drug for weight loss and diabetes, anchored on Phase 3 trials.
Stacks & Blends
Stacks & Blends
"WOLVERINE"
Injury recovery and tissue healing — the flagship healing stack.
“WOLVERINE”
Injury recovery and tissue healing — the flagship healing stack.
"GLOW"
Skin, collagen, and aesthetic recovery — the glow angle.
“GLOW”
Skin, collagen, and aesthetic recovery — the glow angle.
"KLOW"
GLOW + KPV for inflammation and gut — anti-inflammatory upgrade.
“KLOW”
GLOW + KPV for inflammation and gut — anti-inflammatory upgrade.
CJC-1295 + Ipamorelin
Growth-hormone secretagogues for muscle, recovery, anti-aging.
CJC-1295 + Ipamorelin
Growth-hormone secretagogues for muscle, recovery, anti-aging.